Two simple, rapid and economical ‘Zero Order UV - Spectrophotometric (Method I)’ and ‘First Order Derivative Spectrophotometric (Method II)’ using Area Under Curve (AUC) technique were developed for estimation of Cinitapride Hydrogen Tartrate (CNT) in tablet dosage form. In methanol, CNT showed maximum absorbance at 265 nm. In method I, AUC between two wavelengths 260 nm to 270 nm were selected. In method II, UV spectrum of CNT was derivatized into first order and two wavelengths 248 nm to 258 nm were selected for determination of AUC. In both these methods, CNT obeyed linearity in the concentration range of 1-20 μg/ml (r2 = 0.9995) and (r2 = 0.9992). Proposed methods were applied for tablet formulation and amounts of CNT estimated by Method I and Method II were found to be 99.29 + 1.07 and 101.87 + 1.84 respectively. Both these methods were validated statistically and by recovery experiment.
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